BDBM50377937 PROTOPINE
SMILES: CN1CCc2cc3OCOc3cc2C(=O)Cc2cc3OCOc3cc2C1
InChI Key: InChIKey=ZAALQOFZFANFTF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50377937 (PROTOPINE) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois College of Pharmacy Curated by ChEMBL | Assay Description Competitive inhibition of CYP2D6 (unknown origin) using dextromethorphan substrate | J Med Chem 58: 8360-72 (2015) BindingDB Entry DOI: 10.7270/Q29Z96QC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50377937 (PROTOPINE) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tom's of Maine Curated by ChEMBL | Assay Description Inhibition of CYP3A4 | J Nat Prod 69: 432-5 (2006) Article DOI: 10.1021/np058114h BindingDB Entry DOI: 10.7270/Q2V98907 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50377937 (PROTOPINE) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Tom's of Maine Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells | J Nat Prod 69: 432-5 (2006) Article DOI: 10.1021/np058114h BindingDB Entry DOI: 10.7270/Q2V98907 | |||||||||||
More data for this Ligand-Target Pair |