null
SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(N)=O
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human)) | BDBM217366 (Pep2-8 | TVFTSWEEYLDWV) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal His8-tagged PCSK9 expressed in Chinese hamster ovary cells by biolayer interferometry | Bioorg Med Chem Lett 28: 1155-1160 (2018) Article DOI: 10.1016/j.bmcl.2018.02.046 BindingDB Entry DOI: 10.7270/Q2H997VW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human)) | BDBM217366 (Pep2-8 | TVFTSWEEYLDWV) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. | Assay Description For the peptide affinity determinations, biotinylated PCSK9 was immobilized to NeutrAvidin-coated MaxiSorp Immuno-Plates and incubated with a mixture... | J Biol Chem 289: 942-55 (2014) Article DOI: 10.1074/jbc.M113.514067 BindingDB Entry DOI: 10.7270/Q2R2107N | |||||||||||
More data for this Ligand-Target Pair |