BDBM50128581 Biphenyl-3-yl-carbamic acid cyclohexyl ester::CHEMBL77767::URB602::biphenyl-3-ylcarbamic acid cyclohexyl ester::cyclohexyl biphenyl-3-ylcarbamate

SMILES: O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1

InChI Key: InChIKey=HHVUFQYJOSFTEH-UHFFFAOYSA-N

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50128581   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monoglyceride lipase (MGL) (Rattus norvegicus (Rat))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.23E+5	n/a	n/a	n/a	n/a	8.0	n/a
University of California, Irvine					Assay Description The measurement of the ability of URB602 compound to inhibit MGL activity.				Chem Biol 14: 1357-65 (2007) Article DOI: 10.1016/j.chembiol.2007.10.017 BindingDB Entry DOI: 10.7270/Q2XS5SW0
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB MMDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Urbino Carlo Bo Curated by ChEMBL					Assay Description Fatty acid amide hydrolase inhibitory activity in rat brain membrane using [3H]-anandamide as a substrate				J Med Chem 46: 2352-60 (2003) Article DOI: 10.1021/jm021119g BindingDB Entry DOI: 10.7270/Q2DB817C
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Louvain Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human MGL				J Med Chem 52: 7410-20 (2009) Article DOI: 10.1021/jm900461w BindingDB Entry DOI: 10.7270/Q2TM7B59
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Louvain Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human FAAH				J Med Chem 52: 7410-20 (2009) Article DOI: 10.1021/jm900461w BindingDB Entry DOI: 10.7270/Q2TM7B59
					More data for this Ligand-Target Pair
Monoglyceride lipase (MGL) (Rattus norvegicus (Rat))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of MAGL in Wistar rat brain				Nat Chem Biol 5: 37-44 (2008) Article DOI: 10.1038/nchembio.129 BindingDB Entry DOI: 10.7270/Q2DN4582
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universite Catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation counting				J Med Chem 52: 7310-4 (2009) Article DOI: 10.1021/jm901323s BindingDB Entry DOI: 10.7270/Q2319X48
					More data for this Ligand-Target Pair
Monoglyceride lipase (MGL) (Rattus norvegicus (Rat))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical and Pharmaceutical Sciences, University of Ferrara , 44121 Ferrara, Italy. Curated by ChEMBL					Assay Description Inhibition of MAGL from Wistar rat brain using 2-monooleoyl[1,2,3-H]glycerol as substrate				J Med Chem 61: 1340-1354 (2018) Article DOI: 10.1021/acs.jmedchem.7b01845 BindingDB Entry DOI: 10.7270/Q2JM2D3V
					More data for this Ligand-Target Pair
Monoglyceride lipase (MGL) (Rattus norvegicus (Rat))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Inhibition of Wistar rat MAGL using 2-monooleoyl[1,2,3-3H]glycerol as substrate				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of recombinant human MAGL using 7-HRA as substrate preincubated for 60 mins followed by substrate addition by fluorescence assay				Bioorg Med Chem 26: 2561-2572 (2018) Article DOI: 10.1016/j.bmc.2018.04.024 BindingDB Entry DOI: 10.7270/Q2C82CZN
					More data for this Ligand-Target Pair
Monoglyceride Lipase (MGL) (Mus musculus (mouse))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of MAGL in mouse B16-F10 cells using 7-HRA as substrate preincubated for 60 mins followed by substrate addition measured every 2.5 mins fo...				Bioorg Med Chem 26: 2561-2572 (2018) Article DOI: 10.1016/j.bmc.2018.04.024 BindingDB Entry DOI: 10.7270/Q2C82CZN
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50128581 (Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1 Show InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universite Catholique de Louvain Curated by ChEMBL					Assay Description Inhibition of human recombinant FAAH-maltose binding protein				J Med Chem 52: 7310-4 (2009) Article DOI: 10.1021/jm901323s BindingDB Entry DOI: 10.7270/Q2319X48
					More data for this Ligand-Target Pair