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SMILES: COC[C@H]1CN(CCc2ccc(cc2)N2CCC(=O)NC2=O)CCN1c1ccc(Nc2cc(ncn2)-c2ccc([C@@H](C)NC(=O)c3nc(no3)C(C)(C)C)c(C)c2)nc1

InChI Key:

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662961   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein cereblon


(Homo sapiens (Human))
BDBM662961
PNG
(US20240109877, Example 15)
Show SMILES COC[C@H]1CN(CCc2ccc(cc2)N2CCC(=O)NC2=O)CCN1c1ccc(Nc2cc(ncn2)-c2ccc([C@@H](C)NC(=O)c3nc(no3)C(C)(C)C)c(C)c2)nc1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
n/an/a>1.00E+4n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM662961
PNG
(US20240109877, Example 15)
Show SMILES COC[C@H]1CN(CCc2ccc(cc2)N2CCC(=O)NC2=O)CCN1c1ccc(Nc2cc(ncn2)-c2ccc([C@@H](C)NC(=O)c3nc(no3)C(C)(C)C)c(C)c2)nc1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
UniChem
n/an/a 0.0990n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair