BDBM50141073 (E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecarboxamide::4-(4-fluorophenoxy)benzaldehyde semicarbazone::CHEMBL287833::V-102862
SMILES: NC(=O)NN=Cc1ccc(Oc2ccc(F)cc2)cc1
InChI Key: InChIKey=MHUUDVZSPFRUSK-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4) (Homo sapiens (Human)) | BDBM50141073![]() ((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma L.P. Curated by ChEMBL | Assay Description Affinity for inactive human SkM1 sodium channel expressed in HEK293 cells | J Med Chem 47: 1547-52 (2004) Article DOI: 10.1021/jm030498q BindingDB Entry DOI: 10.7270/Q2SX6F0Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50141073![]() ((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Binding affinity to human Nav1.7 | Bioorg Med Chem Lett 20: 5536-40 (2010) Article DOI: 10.1016/j.bmcl.2010.07.064 BindingDB Entry DOI: 10.7270/Q2FB535G | |||||||||||
More data for this Ligand-Target Pair |