BDBM50773 1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol;hydrochloride::1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol;hydrochloride::1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;hydrochloride::1-[4-(2-methoxyphenyl)piperazino]-3-(1-naphthoxy)propan-2-ol;hydrochloride::CHEMBL142635::MLS000069363::NAFTOPIDIL DIHYDROCHLORIDE::SMR000058489::cid_4418::cid_6603044

SMILES: COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1

InChI Key: InChIKey=HRRBJVNMSRJFHQ-UHFFFAOYSA-N

Data: 10 KI  8 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50773   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Medical University Curated by ChEMBL					Assay Description Displacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins				Bioorg Med Chem Lett 28: 547-551 (2018) Article DOI: 10.1016/j.bmcl.2018.01.068 BindingDB Entry DOI: 10.7270/Q2057JHB
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Medical University Curated by ChEMBL					Assay Description Displacement of [125I-HEAT from human alpha1A-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins				Bioorg Med Chem Lett 28: 547-551 (2018) Article DOI: 10.1016/j.bmcl.2018.01.068 BindingDB Entry DOI: 10.7270/Q2057JHB
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active				Bioorg Med Chem Lett 15: 657-64 (2005) Article DOI: 10.1016/j.bmcl.2004.11.032 BindingDB Entry DOI: 10.7270/Q2SN08GW
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to adrenergic alpha1A receptor (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-010-9379-1 BindingDB Entry DOI: 10.7270/Q2NG4THH
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to adrenergic alpha1A receptor (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-010-9379-1 BindingDB Entry DOI: 10.7270/Q2NG4THH
					More data for this Ligand-Target Pair
Adrenergic receptor alpha (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Medical University Curated by ChEMBL					Assay Description Displacement of [125I-HEAT from human alpha1B-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins				Bioorg Med Chem Lett 28: 547-551 (2018) Article DOI: 10.1016/j.bmcl.2018.01.068 BindingDB Entry DOI: 10.7270/Q2057JHB
					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Perugia Curated by ChEMBL					Assay Description Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain				Bioorg Med Chem Lett 10: 465-8 (2000) BindingDB Entry DOI: 10.7270/Q2SJ1JVG
					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (Rattus norvegicus (Rat))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Perugia Curated by ChEMBL					Assay Description Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...				Bioorg Med Chem Lett 10: 465-8 (2000) BindingDB Entry DOI: 10.7270/Q2SJ1JVG
					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Canis familiaris)	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Perugia Curated by ChEMBL					Assay Description Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung				Bioorg Med Chem Lett 10: 465-8 (2000) BindingDB Entry DOI: 10.7270/Q2SJ1JVG
					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Perugia Curated by ChEMBL					Assay Description Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex				Bioorg Med Chem Lett 10: 465-8 (2000) BindingDB Entry DOI: 10.7270/Q2SJ1JVG
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	555	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay				Bioorg Med Chem 23: 7735-42 (2015) Article DOI: 10.1016/j.bmc.2015.11.020 BindingDB Entry DOI: 10.7270/Q2K0779G
					More data for this Ligand-Target Pair
Adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	634	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay				Bioorg Med Chem 23: 7735-42 (2015) Article DOI: 10.1016/j.bmc.2015.11.020 BindingDB Entry DOI: 10.7270/Q2K0779G
					More data for this Ligand-Target Pair
Adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay				Bioorg Med Chem 23: 7735-42 (2015) Article DOI: 10.1016/j.bmc.2015.11.020 BindingDB Entry DOI: 10.7270/Q2K0779G
					More data for this Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d) (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Luoyang Normal University Curated by ChEMBL					Assay Description Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay				Bioorg Med Chem Lett 28: 1534-1539 (2018) Article DOI: 10.1016/j.bmcl.2018.03.070 BindingDB Entry DOI: 10.7270/Q2KW5JNW
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	555	n/a	n/a	n/a	n/a	n/a	n/a
Luoyang Normal University Curated by ChEMBL					Assay Description Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay				Bioorg Med Chem Lett 28: 1534-1539 (2018) Article DOI: 10.1016/j.bmcl.2018.03.070 BindingDB Entry DOI: 10.7270/Q2KW5JNW
					More data for this Ligand-Target Pair
Adrenergic receptor alpha (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	634	n/a	n/a	n/a	n/a	n/a	n/a
Luoyang Normal University Curated by ChEMBL					Assay Description Antagonist activity at alpha 1B adrenergic receptor (unknown origin) by luciferase reporter gene assay				Bioorg Med Chem Lett 28: 1534-1539 (2018) Article DOI: 10.1016/j.bmcl.2018.03.070 BindingDB Entry DOI: 10.7270/Q2KW5JNW
					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
					More data for this Ligand-Target Pair
BZLF2 (Human herpesvirus 4 type 2)	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2057DCW
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM50773 (1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...) Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2B856KG
					More data for this Ligand-Target Pair