BindingDB PrimarySearch

BDBM50208612 (-)-kurarinone::(2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-(5-methyl-2-(prop-1-en-2-yl)hex-4-enyl)chroman-4-one::CHEMBL243796::kurarinone

SMILES: [#6]-[#8]-c1cc(-[#8])c(-[#6]-[#6](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](-[#6])=[#6])c2-[#8]-[#6@@H](-[#6]-[#6](=O)-c12)-c1ccc(-[#8])cc1-[#8]

InChI Key: InChIKey=LTTQKYMNTNISSZ-KESSSICBSA-N

Data: 6 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50208612
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gyeongsang National University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human BACE1				Bioorg Med Chem 16: 6669-74 (2008) Article DOI: 10.1016/j.bmc.2008.05.080 BindingDB Entry DOI: 10.7270/Q2HT2Q74
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake				Bioorg Med Chem 15: 3445-9 (2007) Article DOI: 10.1016/j.bmc.2007.03.011 BindingDB Entry DOI: 10.7270/Q25X28N2
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					Assay Description Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptake				Bioorg Med Chem 15: 3445-9 (2007) Article DOI: 10.1016/j.bmc.2007.03.011 BindingDB Entry DOI: 10.7270/Q25X28N2
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Diacyl Glycerolacyltransferase 1 (DGAT-1) (Rattus norvegicus (rat))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dongguk University-Seoul Curated by ChEMBL					Assay Description Inhibition of DGAT in rat liver microsomes				Bioorg Med Chem Lett 22: 7456-60 (2012) Article DOI: 10.1016/j.bmcl.2012.10.046 BindingDB Entry DOI: 10.7270/Q2WH2R5Z
Dongguk University-Seoul Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of COX1				J Nat Prod 68: 985-91 (2005) Article DOI: 10.1021/np049655u BindingDB Entry DOI: 10.7270/Q27S7PN5
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a
Ghent University Curated by ChEMBL					Assay Description Estrogenic activity at human estrogen receptor expressing Saccharomyces cerevisiae carrying estrogen responsive sequence contatining plasmid assessed...				J Nat Prod 67: 1829-32 (2004) Article DOI: 10.1021/np040069a BindingDB Entry DOI: 10.7270/Q2SN09TS
Ghent University Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a
Ghent University Curated by ChEMBL					Assay Description Estrogenic activity at estrogen receptor in human Ishikawa Var-1 cells assessed as stimulation of alkaline phosphatase activity measured by metabolis...				J Nat Prod 67: 1829-32 (2004) Article DOI: 10.1021/np040069a BindingDB Entry DOI: 10.7270/Q2SN09TS
Ghent University Curated by ChEMBL					More data for this Ligand-Target Pair
Sterol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50208612 ((-)-kurarinone \| (2S)-2-(2,4-dihydroxyphenyl)-7-hy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dongguk University-Seoul Curated by ChEMBL					Assay Description Inhibition of human macrophage ACAT expressed in human HepG2 cells using [14C]oleoyl-CoA as substrate incubated for 20 mins prior to substrate additi...				Eur J Med Chem 62: 515-25 (2013) Article DOI: 10.1016/j.ejmech.2013.01.020 BindingDB Entry DOI: 10.7270/Q29G5P5N
Dongguk University-Seoul Curated by ChEMBL					More data for this Ligand-Target Pair