BDBM102058 US9695165, 4

SMILES: COc1cc(OC)cc(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F

InChI Key: InChIKey=CVDUKEWPLFFDGS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102058   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102058 (US9695165, 4) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C28H26FN3O4/c1-6-27(33)31-19-7-8-24(29)23(12-19)25-14-26-18(15-30-25)11-22(28(34)32(26)16(2)3)17-9-20(35-4)13-21(10-17)36-5/h6-16H,1H2,2-5H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102058 (US9695165, 4) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C28H26FN3O4/c1-6-27(33)31-19-7-8-24(29)23(12-19)25-14-26-18(15-30-25)11-22(28(34)32(26)16(2)3)17-9-20(35-4)13-21(10-17)36-5/h6-16H,1H2,2-5H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair