Found 4 hits for monomerid = 102177 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM102177
(US8530648, 107)Show SMILES O=C1N(Cc2c[nH]c3ccccc23)CCCC11CCN(CC1)c1cnc2ccccc2c1 Show InChI InChI=1S/C27H28N4O/c32-26-27(10-5-13-31(26)19-21-17-28-25-9-4-2-7-23(21)25)11-14-30(15-12-27)22-16-20-6-1-3-8-24(20)29-18-22/h1-4,6-9,16-18,28H,5,10-15,19H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Novartis AG
US Patent
| Assay Description FLIPR assay using orexin receptor. |
US Patent US8530648 (2013)
BindingDB Entry DOI: 10.7270/Q2SB44DR |
More data for this Ligand-Target Pair | |
Orexin receptor type 1
(Homo sapiens (Human)) | BDBM102177
(US8530648, 107)Show SMILES O=C1N(Cc2c[nH]c3ccccc23)CCCC11CCN(CC1)c1cnc2ccccc2c1 Show InChI InChI=1S/C27H28N4O/c32-26-27(10-5-13-31(26)19-21-17-28-25-9-4-2-7-23(21)25)11-14-30(15-12-27)22-16-20-6-1-3-8-24(20)29-18-22/h1-4,6-9,16-18,28H,5,10-15,19H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Novartis AG
US Patent
| Assay Description FLIPR assay using orexin receptor. |
US Patent US8530648 (2013)
BindingDB Entry DOI: 10.7270/Q2SB44DR |
More data for this Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM102177
(US8530648, 107)Show SMILES O=C1N(Cc2c[nH]c3ccccc23)CCCC11CCN(CC1)c1cnc2ccccc2c1 Show InChI InChI=1S/C27H28N4O/c32-26-27(10-5-13-31(26)19-21-17-28-25-9-4-2-7-23(21)25)11-14-30(15-12-27)22-16-20-6-1-3-8-24(20)29-18-22/h1-4,6-9,16-18,28H,5,10-15,19H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | 147 | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description Radioligand binding assay using orexin receptor. |
US Patent US8530648 (2013)
BindingDB Entry DOI: 10.7270/Q2SB44DR |
More data for this Ligand-Target Pair | |
Orexin receptor type 1
(Homo sapiens (Human)) | BDBM102177
(US8530648, 107)Show SMILES O=C1N(Cc2c[nH]c3ccccc23)CCCC11CCN(CC1)c1cnc2ccccc2c1 Show InChI InChI=1S/C27H28N4O/c32-26-27(10-5-13-31(26)19-21-17-28-25-9-4-2-7-23(21)25)11-14-30(15-12-27)22-16-20-6-1-3-8-24(20)29-18-22/h1-4,6-9,16-18,28H,5,10-15,19H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | 1.84E+3 | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG
US Patent
| Assay Description Radioligand binding assay using orexin receptor. |
US Patent US8530648 (2013)
BindingDB Entry DOI: 10.7270/Q2SB44DR |
More data for this Ligand-Target Pair | |