null

SMILES: CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC

InChI Key: InChIKey=UNRZERCRSJMUJU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 103856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103856 (US9695165, 39) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC |(4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;.67,5.39,;-.67,6.16,;-2,5.39,;-.67,7.7,;-2,8.47,;-3.33,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;3.33,10.01,;2,6.16,;3.33,5.39,;2,3.08,;3.33,3.85,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;.67,-8.47,;3.33,-8.47,;3.33,-10.01,;-.67,-6.16,;-2,-5.39,;-2,-3.85,;-3.33,-3.08,;-4.67,-3.85,)| Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103856 (US9695165, 39) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC |(4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;.67,5.39,;-.67,6.16,;-2,5.39,;-.67,7.7,;-2,8.47,;-3.33,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;3.33,10.01,;2,6.16,;3.33,5.39,;2,3.08,;3.33,3.85,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;.67,-8.47,;3.33,-8.47,;3.33,-10.01,;-.67,-6.16,;-2,-5.39,;-2,-3.85,;-3.33,-3.08,;-4.67,-3.85,)| Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair