BDBM107698 US8598210, Table XV, 4::US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridine-2- carbonyl)amino]-acetic acid::US9598370, Example 00129::USRE47437, Example [(3-Hydroxy-5-(4-methylphenyl)pyridine-2-carbonyl)amino]-acetic acid
SMILES: Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
InChI Key: InChIKey=VBNCAZJDNCXKIO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 4.21E+4 | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US8598210 (2013) BindingDB Entry DOI: 10.7270/Q2M04428 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | 25 |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | 25 |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US8722895 (2014) BindingDB Entry DOI: 10.7270/Q25Q4TRQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of recombinant human PHD2 (179 to 426 residues) using HIF-1alpha (556 to 574 residues) as substrate after 20 mins by MALDI-TOF MS analysis | ACS Med Chem Lett 6: 1236-40 (2015) BindingDB Entry DOI: 10.7270/Q2RB76G9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 4.21E+4 | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | Assay Description HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight... | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor A (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 4.21E+4 | n/a | n/a | n/a | n/a |
Akebia Therapeutics, Inc. US Patent | US Patent US9598370 (2017) BindingDB Entry DOI: 10.7270/Q20G3N64 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California at Los Angeles | Assay Description The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T... | Bioorg Med Chem 17: 7174-85 (2009) BindingDB Entry DOI: 10.7270/Q2D50Q9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM107698 (US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass... | ACS Med Chem Lett 6: 1236-40 (2015) BindingDB Entry DOI: 10.7270/Q2RB76G9 | |||||||||||
More data for this Ligand-Target Pair |