BDBM111823 BDBM111857::US8623906, JHE-02-001::US8623906, JHE-02-067::US8623906, JHE-02-069::US9174969, JHE-02-069
SMILES: OC(CC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(Cl)c1)C(O)=O
InChI Key: InChIKey=BPWVOFBXHLAILC-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute, Inc. US Patent | Assay Description In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro... | US Patent US8623906 (2014) BindingDB Entry DOI: 10.7270/Q22R3QB4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute, Inc. US Patent | Assay Description In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro... | US Patent US8623906 (2014) BindingDB Entry DOI: 10.7270/Q22R3QB4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF SOUTH FLORIDA US Patent | Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. | US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF SOUTH FLORIDA US Patent | Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. | US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF SOUTH FLORIDA US Patent | Assay Description IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. | US Patent US9174969 (2015) BindingDB Entry DOI: 10.7270/Q20R9N65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM111823 (BDBM111857 | US8623906, JHE-02-001 | US8623906, JH...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute, Inc. US Patent | Assay Description In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro... | US Patent US8623906 (2014) BindingDB Entry DOI: 10.7270/Q22R3QB4 | |||||||||||
More data for this Ligand-Target Pair |