BDBM112600 US8618103, I-96
SMILES: CN1CCC(CC1)Nc1ncc(c(N[C@H]2CCCN(C2)S(C)(=O)=O)n1)-c1cnc2[nH]ccc2n1
InChI Key: InChIKey=GKMDQFMGAVLZKR-INIZCTEOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM112600 (US8618103, I-96) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.0125 | n/a | 0.0251 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. | US Patent US8618103 (2013) BindingDB Entry DOI: 10.7270/Q25H7DZH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM112600 (US8618103, I-96) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.108 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. | US Patent US8618103 (2013) BindingDB Entry DOI: 10.7270/Q25H7DZH | |||||||||||
More data for this Ligand-Target Pair |