BDBM113392 US10336717, Compound 578::US8633212, 578::US9212153, 578
SMILES: CO[C@H]1CC[C@@]2(Cc3ccc(Oc4ccccc4)cc3[C@]22N=C(N)N(C)C2=O)CC1
InChI Key: InChIKey=DVSMPRORXNHICB-UOKFIYJESA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113392 (US10336717, Compound 578 | US8633212, 578 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM113392 (US10336717, Compound 578 | US8633212, 578 | US9212...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC Curated by PubChem BioAssay | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2WH2NCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-458] (Homo sapiens (Human)) | BDBM113392 (US10336717, Compound 578 | US8633212, 578 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US9212153 (2015) BindingDB Entry DOI: 10.7270/Q2J67FRJ | |||||||||||
More data for this Ligand-Target Pair |