BDBM120727 US8703768, 328

SMILES: CNC(=O)c1cc(CCC(O)=O)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1

InChI Key: InChIKey=DBNDSDTWULRLLN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 120727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM120727 (US8703768, 328) Show SMILES CNC(=O)c1cc(CCC(O)=O)ccc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1 Show InChI InChI=1S/C23H23N7O4/c1-24-22(33)16-8-13(3-7-19(31)32)2-6-17(16)30-23(34)20-21(28-15-9-25-12-26-10-15)27-11-18(29-20)14-4-5-14/h2,6,8-12,14H,3-5,7H2,1H3,(H,24,33)(H,27,28)(H,30,34)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8703768 (2014) BindingDB Entry DOI: 10.7270/Q27P8X37
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