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SMILES: O[C@H]1CC[C@]2(CCN(C2=O)c2ccc(OC(F)(F)F)cc2)C[C@@H]1OCC(F)(F)F

InChI Key: InChIKey=PPWLUVUZMIXMJC-DZKIICNBSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 121027   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hormone-sensitive lipase


(Homo sapiens (Human))		BDBM121027
PNG
(US8722721, 7)
Show SMILES O[C@H]1CC[C@]2(CCN(C2=O)c2ccc(OC(F)(F)F)cc2)C[C@@H]1OCC(F)(F)F |r|
Show InChI InChI=1S/C18H19F6NO4/c19-17(20,21)10-28-14-9-16(6-5-13(14)26)7-8-25(15(16)27)11-1-3-12(4-2-11)29-18(22,23)24/h1-4,13-14,26H,5-10H2/t13-,14-,16-/m0/s1
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Similars
US Patent
n/an/a 42.1n/an/an/an/a7.24



Hoffmann-La Roche Inc.

US Patent


Assay Description
HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...

US Patent US8722721 (2014)


BindingDB Entry DOI: 10.7270/Q2F76B7M
More data for this
Ligand-Target Pair