BDBM12177 2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]carbonyl}-2,3-dihydro-1H-isoindole::pyrrolidine-2,4-dicarboxylic acid amide 8m

SMILES: FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1

InChI Key: InChIKey=VJUQFPMKSWQOBY-GJZGRUSLSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12177   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM12177 (2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...) Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1 |r| Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	129	n/a	n/a	n/a	n/a	8.0	37
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				Bioorg Med Chem Lett 16: 3268-72 (2006) Article DOI: 10.1016/j.bmcl.2006.03.037 BindingDB Entry DOI: 10.7270/Q22805V8
					More data for this Ligand-Target Pair
Fibroblast Activation Protein (FAP) (Homo sapiens (Human))	BDBM12177 (2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...) Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1 |r| Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				Bioorg Med Chem Lett 16: 3268-72 (2006) Article DOI: 10.1016/j.bmcl.2006.03.037 BindingDB Entry DOI: 10.7270/Q22805V8
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM12177 (2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...) Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1 |r| Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				Bioorg Med Chem Lett 16: 3268-72 (2006) Article DOI: 10.1016/j.bmcl.2006.03.037 BindingDB Entry DOI: 10.7270/Q22805V8
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM12177 (2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...) Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1 |r| Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes					Assay Description The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...				Bioorg Med Chem Lett 16: 3268-72 (2006) Article DOI: 10.1016/j.bmcl.2006.03.037 BindingDB Entry DOI: 10.7270/Q22805V8
					More data for this Ligand-Target Pair