null

SMILES: F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key: InChIKey=DITJAQDLMCTKAT-IPMKNSEASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 127688   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	699	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	699	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	699	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	699	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	699	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127688 (US10251889, Example 61 | US10758542, Example 61 | ...) Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.95	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair