null

SMILES: Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1

InChI Key: InChIKey=OXVCBPXLNVQEGM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 127817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [886-1187] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak1: Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak3: Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Tyk2: Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127817 (US10758542, Example 190 | US8791123, 190 | US97824...) Show SMILES Cc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1 Show InChI InChI=1S/C21H23FN6O/c1-13-15(10-14(22)11-23-13)17-4-3-8-27(17)18-5-9-28-19(25-18)16(12-24-28)20(29)26-21(2)6-7-21/h5,9-12,17H,3-4,6-8H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair