null

SMILES: Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O

InChI Key: InChIKey=QJFLYXFEPUKNII-HFLHWUEFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 127865   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127865 (US10251889, Example 238 | US10758542, Example 238 ...) Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)| Show InChI InChI=1S/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair