BDBM131859 US8835444, 1.4
SMILES: OC(=O)Cc1ccc(NC[C@H]2CC[C@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)cc1
InChI Key: InChIKey=CDUUPHUMLLMQEX-RHNCMZPLSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin releasing factor receptor 1 (Homo sapiens (Human)) | BDBM131859 (US8835444, 1.4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 948 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89... | US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST | |||||||||||
More data for this Ligand-Target Pair |