BDBM13313 N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-ylmethyl)amino]ethyl}benzenesulfonamide::N-benzyl-N-{2-[(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl}benzenesulfonamide::Sulfonamide 12e
SMILES: Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccc(cc1)C#N
InChI Key: InChIKey=OHMYEZKFMQAYKQ-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) (Plasmodium falciparum (malaria parasite P. falcipa...) | BDBM13313 (N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Yale University | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 5710-27 (2006) Article DOI: 10.1021/jm060081v BindingDB Entry DOI: 10.7270/Q2G44NJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase (Rattus norvegicus (rat)) | BDBM13313 (N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Yale University | Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal... | J Med Chem 49: 5710-27 (2006) Article DOI: 10.1021/jm060081v BindingDB Entry DOI: 10.7270/Q2G44NJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus) | BDBM13313 (N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells | J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type 1 (Mus musculus) | BDBM13313 (N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of Rap1A geranylgeranylation expressed in mouse NIH3T3 cells | J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM13313 (N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of human geranylgeranyltransferase-1 assessed as incorporation of [3H]GGPP into H-Ras-CVLL | J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM13313 (N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS | J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC | |||||||||||
More data for this Ligand-Target Pair |