BDBM135045 US8846698, 530

SMILES: CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cn3)C#N)c2)c2cnc(N)nc12

InChI Key: InChIKey=FLORASYUXJBGTC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 135045   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM135045 (US8846698, 530) Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cn3)C#N)c2)c2cnc(N)nc12 Show InChI InChI=1S/C24H22N8O2/c1-24(2,3)32-13-19(18-12-29-23(26)31-22(18)32)21(34)15-6-17(11-27-10-15)30-20(33)7-16-5-4-14(8-25)9-28-16/h4-6,9-13H,7H2,1-3H3,(H,30,33)(H2,26,29,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
					More data for this Ligand-Target Pair