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BDBM135089 US8846698, 577

SMILES: CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C3CC3)c2)c2cnc(N)nc12

InChI Key: InChIKey=GOWGVAKEBBJARV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 135089   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM135089
PNG
(US8846698, 577)
Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(cn3)C3CC3)c2)c2cnc(N)nc12
Show InChI InChI=1S/C24H26N8O2/c1-24(2,3)32-12-19(18-10-27-23(25)30-22(18)32)21(34)15-6-17(9-26-7-15)29-20(33)13-31-11-16(8-28-31)14-4-5-14/h6-12,14H,4-5,13H2,1-3H3,(H,29,33)(H2,25,27,30)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...


US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair