BDBM136549 US8865701, 30::US9505739, 30

SMILES: Brc1ccc2c(CC[C@]22CNC[C@H]2C(=O)N2CCC(CC2)c2ccccc2)c1

InChI Key: InChIKey=OYCCZVYNVGVLPV-UPVQGACJSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 136549   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM136549 (US8865701, 30 | US9505739, 30) Show SMILES Brc1ccc2c(CC[C@]22CNC[C@H]2C(=O)N2CCC(CC2)c2ccccc2)c1 |r| Show InChI InChI=1S/C24H27BrN2O/c25-20-6-7-21-19(14-20)8-11-24(21)16-26-15-22(24)23(28)27-12-9-18(10-13-27)17-4-2-1-3-5-17/h1-7,14,18,22,26H,8-13,15-16H2/t22-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	6.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A homogeneous end point electrochemiluminescence (ECL) assay is performed using a biotinylated BACE substrate. The Km of the substrate is approximate...				US Patent US9505739 (2016) BindingDB Entry DOI: 10.7270/Q2C53JST
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM136549 (US8865701, 30 | US9505739, 30) Show SMILES Brc1ccc2c(CC[C@]22CNC[C@H]2C(=O)N2CCC(CC2)c2ccccc2)c1 |r| Show InChI InChI=1S/C24H27BrN2O/c25-20-6-7-21-19(14-20)8-11-24(21)16-26-15-22(24)23(28)27-12-9-18(10-13-27)17-4-2-1-3-5-17/h1-7,14,18,22,26H,8-13,15-16H2/t22-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	6.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A homogeneous end point electrochemiluminescence (ECL) assay is performed using a biotinylated BACE substrate. The Km of the substrate is approximate...				US Patent US8865701 (2014) BindingDB Entry DOI: 10.7270/Q2KP80V1
					More data for this Ligand-Target Pair