BDBM138205 US8871778, 163

SMILES: CC(C)n1nc(Cl)c2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12

InChI Key: InChIKey=UVFZHIQEWCFGHT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 138205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM138205 (US8871778, 163) Show SMILES CC(C)n1nc(Cl)c2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C22H25ClN8O/c1-13(2)31-19-5-4-16(8-18(19)21(23)28-31)25-22-24-7-6-20(26-22)30-10-15(14(3)27-30)9-29-11-17(32)12-29/h4-8,10,13,17,32H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM138205 (US8871778, 163) Show SMILES CC(C)n1nc(Cl)c2cc(Nc3nccc(n3)-n3cc(CN4CC(O)C4)c(C)n3)ccc12 Show InChI InChI=1S/C22H25ClN8O/c1-13(2)31-19-5-4-16(8-18(19)21(23)28-31)25-22-24-7-6-20(26-22)30-10-15(14(3)27-30)9-29-11-17(32)12-29/h4-8,10,13,17,32H,9,11-12H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a	25
Genosco; Oscotec, Inc. US Patent					Assay Description Compounds of the invention were initially diluted to 10 mM in 100% DMSO (CALBIOCHEM) for storage and made into kinase buffer solution to create a com...				US Patent US8871778 (2014) BindingDB Entry DOI: 10.7270/Q2X065R6
					More data for this Ligand-Target Pair