BDBM140282 US8912173, 8

SMILES: COc1ccc(cc1OC)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1

InChI Key: InChIKey=PTFFLUCLCIXDME-RHSMWYFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140282   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140282 (US8912173, 8) Show SMILES COc1ccc(cc1OC)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1 |r| Show InChI InChI=1S/C23H24N2O4/c1-14(17-12-23(26)25-13-17)29-21-11-16(9-19-18(21)5-4-8-24-19)15-6-7-20(27-2)22(10-15)28-3/h4-11,14,17H,12-13H2,1-3H3,(H,25,26)/t14-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair