null

SMILES: CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCC(O)CC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C

InChI Key: InChIKey=IIZXQQZRRXYLSE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 143353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Mdm4 (Homo sapiens (Human))	BDBM143353 (US8969341, 19) Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCC(O)CC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C Show InChI InChI=1S/C29H32Cl2N4O3/c1-16(2)27-25-26(32-34(27)15-24(37)33-11-9-21(36)10-12-33)29(38)35(23-14-20(31)6-5-17(23)3)28(25)22-8-7-19(30)13-18(22)4/h5-8,13-14,16,21,28,36H,9-12,15H2,1-4H3	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM143353 (US8969341, 19) Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)N1CCC(O)CC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C Show InChI InChI=1S/C29H32Cl2N4O3/c1-16(2)27-25-26(32-34(27)15-24(37)33-11-9-21(36)10-12-33)29(38)35(23-14-20(31)6-5-17(23)3)28(25)22-8-7-19(30)13-18(22)4/h5-8,13-14,16,21,28,36H,9-12,15H2,1-4H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair