null

SMILES: COC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1

InChI Key: InChIKey=PDQMWNKSPGNNOB-CALCHBBNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144697 (US8952037, 70) Show SMILES COC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:17.18,19.23,(-3.32,3.91,;-4.65,4.68,;-5.98,3.91,;-7.07,4.99,;-5.98,2.37,;-7.32,1.54,;-7.32,,;-5.98,-.77,;-4.65,,;-4.65,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-.5,-2.68,;-.1,-4.17,;-1.58,-4.57,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C23H26N4O3S/c1-29-23(28)27-11-8-15(9-12-27)18-5-4-10-24-21(18)30-17-13-16(14-17)25-22-26-19-6-2-3-7-20(19)31-22/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,25,26)/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.18	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair