BDBM145822 US8952177, 178::US9089569, 178::US9695149, 178

SMILES: CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1

InChI Key: InChIKey=QDVBYODHCQMBIK-IZLXSDGUSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145822   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145822 (US8952177, 178 | US9089569, 178 | US9695149, 178) Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| Show InChI InChI=1S/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145822 (US8952177, 178 | US9089569, 178 | US9695149, 178) Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| Show InChI InChI=1S/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145822 (US8952177, 178 | US9089569, 178 | US9695149, 178) Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)cc1 |r| Show InChI InChI=1S/C34H39FN4O3/c1-22-13-15-38(16-14-22)25-9-7-24(8-10-25)20-39-32-18-26(42-21-31-29(35)17-23(2)19-36-31)11-12-30(32)37-33(39)27-5-3-4-6-28(27)34(40)41/h7-12,17-19,22,27-28H,3-6,13-16,20-21H2,1-2H3,(H,40,41)/t27-,28+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair