BDBM146890 US8957073, 24.3::US9718803, 24.3

SMILES: NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1

InChI Key: InChIKey=RDISXHYFVLOZDN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 146890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM146890 (US8957073, 24.3 | US9718803, 24.3) Show SMILES NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H24N6O/c23-21(29)16-7-11-27(12-8-16)22-20(24-9-10-25-22)17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...				US Patent US9718803 (2017) BindingDB Entry DOI: 10.7270/Q2J968DN
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM146890 (US8957073, 24.3 | US9718803, 24.3) Show SMILES NC(=O)C1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C22H24N6O/c23-21(29)16-7-11-27(12-8-16)22-20(24-9-10-25-22)17-13-28(14-17)19-6-5-15-3-1-2-4-18(15)26-19/h1-6,9-10,16-17H,7-8,11-14H2,(H2,23,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...				US Patent US8957073 (2015) BindingDB Entry DOI: 10.7270/Q2PR7TPZ
					More data for this Ligand-Target Pair