Found 6 hits for monomerid = 14752 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphodiesterase Type 10 (PDE10A)
(Rattus norvegicus (rat)) | BDBM14752
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC |r| Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 68 | -9.67 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer
| Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by... |
J Med Chem 50: 182-5 (2007)
Article DOI: 10.1021/jm060653b BindingDB Entry DOI: 10.7270/Q2930RDX |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM14752
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC |r| Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. John's University
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem 16: 3675-86 (2008)
Article DOI: 10.1016/j.bmc.2008.02.013 BindingDB Entry DOI: 10.7270/Q2V988ZC |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3 (PDE3)
(Homo sapiens (Human)) | BDBM14752
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC |r| Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. John's University
Curated by ChEMBL
| Assay Description Inhibition of PDE3A |
Bioorg Med Chem 16: 3675-86 (2008)
Article DOI: 10.1016/j.bmc.2008.02.013 BindingDB Entry DOI: 10.7270/Q2V988ZC |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3 (PDE3)
(Homo sapiens (Human)) | BDBM14752
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC |r| Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by... |
J Med Chem 50: 182-5 (2007)
Article DOI: 10.1021/jm060653b BindingDB Entry DOI: 10.7270/Q2930RDX |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
(Homo sapiens (Human)) | BDBM14752
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC |r| Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 237 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. John's University
Curated by ChEMBL
| Assay Description Inhibition of PDE3B |
Bioorg Med Chem 16: 3675-86 (2008)
Article DOI: 10.1016/j.bmc.2008.02.013 BindingDB Entry DOI: 10.7270/Q2V988ZC |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
(Homo sapiens (Human)) | BDBM14752
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC |r| Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 237 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer
| Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by... |
J Med Chem 50: 182-5 (2007)
Article DOI: 10.1021/jm060653b BindingDB Entry DOI: 10.7270/Q2930RDX |
More data for this Ligand-Target Pair | |