BDBM148977 US10512644, Compound Morphine::US8962646, A
SMILES: CN1CC[C@@]23[C@H]4Oc5c2c(CC1C3C=C[C@@H]4O)ccc5O
InChI Key: InChIKey=BQJCRHHNABKAKU-WLMSZDCBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | 0.320 | -12.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Alkermes, Inc. US Patent | Assay Description Receptor Binding (in vitro Assay) The Ki (binding affinity) for mu-, delta-, and kippa-receptors was determined with a previously described method us... | US Patent US8962646 (2015) BindingDB Entry DOI: 10.7270/Q2C8280V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | 8.44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Inheris Pharmaceuticals, Inc. US Patent | Assay Description Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con... | US Patent US10512644 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B8V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | 11 | -10.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Alkermes, Inc. US Patent | Assay Description Receptor Binding (in vitro Assay) The Ki (binding affinity) for mu-, delta-, and kippa-receptors was determined with a previously described method us... | US Patent US8962646 (2015) BindingDB Entry DOI: 10.7270/Q2C8280V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | 118 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Inheris Pharmaceuticals, Inc. US Patent | Assay Description Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con... | US Patent US10512644 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B8V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | 230 | -9.05 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Alkermes, Inc. US Patent | Assay Description Receptor Binding (in vitro Assay) The Ki (binding affinity) for mu-, delta-, and kippa-receptors was determined with a previously described method us... | US Patent US8962646 (2015) BindingDB Entry DOI: 10.7270/Q2C8280V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Inheris Pharmaceuticals, Inc. US Patent | Assay Description Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con... | US Patent US10512644 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B8V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 624 | n/a | n/a | n/a | n/a |
Inheris Pharmaceuticals, Inc. US Patent | Assay Description Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan... | US Patent US10512644 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B8V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM148977![]() (US10512644, Compound Morphine | US8962646, A) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 28.5 | n/a | n/a | n/a | n/a |
Inheris Pharmaceuticals, Inc. US Patent | Assay Description Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan... | US Patent US10512644 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B8V | |||||||||||
More data for this Ligand-Target Pair |