BDBM153108 US8993631, 16-5::US9006249, Example 3-32::US9603819, Example 3-32
SMILES: C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(ncn1)C(O)=O)C(O)=O
InChI Key: InChIKey=RPPNGIBDLYBJPM-BEFAXECRSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neprilysin (Homo sapiens (Human)) | BDBM153108 (US8993631, 16-5 | US9006249, Example 3-32 | US9603...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ... | US Patent US9006249 (2015) BindingDB Entry DOI: 10.7270/Q2NV9H0R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neprilysin (Homo sapiens (Human)) | BDBM153108 (US8993631, 16-5 | US9006249, Example 3-32 | US9603...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ... | US Patent US9603819 (2017) BindingDB Entry DOI: 10.7270/Q20V8FVV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral endopeptidase (NEP) (Homo sapiens (Human)) | BDBM153108 (US8993631, 16-5 | US9006249, Example 3-32 | US9603...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat... | US Patent US8993631 (2015) BindingDB Entry DOI: 10.7270/Q20C4THK | |||||||||||
More data for this Ligand-Target Pair |