BDBM153292 3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-yl)-4,5-dihydro-pyrazole-1-carboxylic acid(4-chloro-phenyl)-amide (1b)

SMILES: CN(C)c1ccc(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c2ccccc12

InChI Key: InChIKey=SIQTZSSZFTYKGY-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 153292   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Secretory phospholipase A2, group V (sPLA2-V) (Homo sapiens (Human))	BDBM153292 (3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...) Show SMILES CN(C)c1ccc(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c2ccccc12 |c:9| Show InChI InChI=1S/C30H25ClN4O2/c1-34(2)26-16-15-24(22-8-4-5-9-23(22)26)27-18-25(29-17-19-7-3-6-10-28(19)37-29)33-35(27)30(36)32-21-13-11-20(31)12-14-21/h3-17,27H,18H2,1-2H3,(H,32,36)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	7.5	25
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz					Assay Description Briefly, sn-2ester bond of the substrate 1,2-bis(heptanoylthio)-glycerophosphocholine was hydrolyzed by PLA2-V followed by the exposure of free thiol...				Chem Biol Drug Des 85: 729-42 (2015) Article DOI: 10.1111/cbdd.12457 BindingDB Entry DOI: 10.7270/Q26W98TX
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM153292 (3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...) Show SMILES CN(C)c1ccc(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c2ccccc12 |c:9| Show InChI InChI=1S/C30H25ClN4O2/c1-34(2)26-16-15-24(22-8-4-5-9-23(22)26)27-18-25(29-17-19-7-3-6-10-28(19)37-29)33-35(27)30(36)32-21-13-11-20(31)12-14-21/h3-17,27H,18H2,1-2H3,(H,32,36)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of KwaZulu Natal Curated by ChEMBL					Assay Description Inhibition of diphenolase activity of mushroom tyrosinase pre-incubated for 30 mins before L-DOPA substrate addition and measured after 1 min by spec...				Eur J Med Chem 142: 179-212 (2017) Article DOI: 10.1016/j.ejmech.2017.07.033 BindingDB Entry DOI: 10.7270/Q2DR2Z6Z
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM153292 (3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...) Show SMILES CN(C)c1ccc(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c2ccccc12 |c:9| Show InChI InChI=1S/C30H25ClN4O2/c1-34(2)26-16-15-24(22-8-4-5-9-23(22)26)27-18-25(29-17-19-7-3-6-10-28(19)37-29)33-35(27)30(36)32-21-13-11-20(31)12-14-21/h3-17,27H,18H2,1-2H3,(H,32,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	8.0	25
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz					Assay Description 100 mM Tris¿HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...				Chem Biol Drug Des 85: 729-42 (2015) Article DOI: 10.1111/cbdd.12457 BindingDB Entry DOI: 10.7270/Q26W98TX
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM153292 (3-Benzofuran-2-yl-5-(4-dimethylamino-naphthalen-1-...) Show SMILES CN(C)c1ccc(C2CC(=NN2C(=O)Nc2ccc(Cl)cc2)c2cc3ccccc3o2)c2ccccc12 |c:9| Show InChI InChI=1S/C30H25ClN4O2/c1-34(2)26-16-15-24(22-8-4-5-9-23(22)26)27-18-25(29-17-19-7-3-6-10-28(19)37-29)33-35(27)30(36)32-21-13-11-20(31)12-14-21/h3-17,27H,18H2,1-2H3,(H,32,36)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	8.0	25
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz					Assay Description 100 mM Tris¿HCl buffer, pH 8.0 containing 1 µM heme and COX-1 (ovine) or COX-2(human recombinant), which was preincubated for 10 min in a water bath ...				Chem Biol Drug Des 85: 729-42 (2015) Article DOI: 10.1111/cbdd.12457 BindingDB Entry DOI: 10.7270/Q26W98TX
					More data for this Ligand-Target Pair