BindingDB logo
myBDB logout

null

SMILES: OC(=O)c1cc(F)cc2[nH]c(nc12)-c1ccc(cc1)-c1cccnc1

InChI Key: InChIKey=FCOBGDQSHXUNQQ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 155431   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM155431
PNG
(US9006454, I58)
Show SMILES OC(=O)c1cc(F)cc2[nH]c(nc12)-c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C19H12FN3O2/c20-14-8-15(19(24)25)17-16(9-14)22-18(23-17)12-5-3-11(4-6-12)13-2-1-7-21-10-13/h1-10H,(H,22,23)(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 437n/an/an/an/a8.0n/a



Merck Serono S.A.

US Patent


Assay Description
The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...

US Patent US9006454 (2015)


BindingDB Entry DOI: 10.7270/Q2125RCJ
More data for this
Ligand-Target Pair