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SMILES: Cc1nc(NC(c2ccc(Cl)c(Cl)c2)c2ccc3cccnc3c2O)c(Cl)cc1Cl

InChI Key: InChIKey=HZGVFSASJNRQAV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 156626   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM156626
PNG
(US9023354, AD4-13202)
Show SMILES Cc1nc(NC(c2ccc(Cl)c(Cl)c2)c2ccc3cccnc3c2O)c(Cl)cc1Cl
Show InChI InChI=1S/C22H15Cl4N3O/c1-11-16(24)10-18(26)22(28-11)29-19(13-5-7-15(23)17(25)9-13)14-6-4-12-3-2-8-27-20(12)21(14)30/h2-10,19,30H,1H3,(H,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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Similars
US Patent
n/an/a 1.00E+4n/an/an/an/an/a25



TBA

US Patent


Assay Description
The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...

US Patent US9023354 (2015)


BindingDB Entry DOI: 10.7270/Q26M35KH
More data for this
Ligand-Target Pair