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BDBM159695 US9035059, 14-18

SMILES: CCCCCOc1ccc(NS(=O)(=O)c2ccc3CN(Cc3c2)C(=O)Nc2ccc(cc2)C(C)(C)C)c(F)c1

InChI Key: InChIKey=HCLVCLSUVTYAOF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 159695   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2)


(Homo sapiens (Human))
BDBM159695
PNG
(US9035059, 14-18)
Show SMILES CCCCCOc1ccc(NS(=O)(=O)c2ccc3CN(Cc3c2)C(=O)Nc2ccc(cc2)C(C)(C)C)c(F)c1
Show InChI InChI=1S/C30H36FN3O4S/c1-5-6-7-16-38-25-13-15-28(27(31)18-25)33-39(36,37)26-14-8-21-19-34(20-22(21)17-26)29(35)32-24-11-9-23(10-12-24)30(2,3)4/h8-15,17-18,33H,5-7,16,19-20H2,1-4H3,(H,32,35)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 147n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGAT2 assessed as reduction in enzyme-mediated deacylation of oleoyl-CoA incubated for 20 mins by CPM dye based fluor...


Bioorg Med Chem 23: 5922-31 (2015)


BindingDB Entry DOI: 10.7270/Q2639RJ6
More data for this
Ligand-Target Pair
Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2)


(Homo sapiens (Human))
BDBM159695
PNG
(US9035059, 14-18)
Show SMILES CCCCCOc1ccc(NS(=O)(=O)c2ccc3CN(Cc3c2)C(=O)Nc2ccc(cc2)C(C)(C)C)c(F)c1
Show InChI InChI=1S/C30H36FN3O4S/c1-5-6-7-16-38-25-13-15-28(27(31)18-25)33-39(36,37)26-14-8-21-19-34(20-22(21)17-26)29(35)32-24-11-9-23(10-12-24)30(2,3)4/h8-15,17-18,33H,5-7,16,19-20H2,1-4H3,(H,32,35)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 147n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
A test for MGAT2 inhibitory action of test compounds was conducted in accordance with a partially modified version of the method described in John F....


US Patent US9035059 (2015)


BindingDB Entry DOI: 10.7270/Q2B856WH
More data for this
Ligand-Target Pair