BDBM161451 US10124003, Ex. Compound 64::US10835536, Ex. Comp 64::US10894048, Ex Comp 64::US9108973, 64

SMILES: COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12

InChI Key: InChIKey=FXNCSORTIDLEQF-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 161451   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161451 (US10124003, Ex. Compound 64 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C24H25N5O3/c1-4-21(30)28-9-7-18(8-10-28)29-14-17(22-23(25)26-15-27-24(22)29)6-5-16-11-19(31-2)13-20(12-16)32-3/h4,11-15,18H,1,7-10H2,2-3H3,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	7.5	25
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US9108973 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HJV
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161451 (US10124003, Ex. Compound 64 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C24H25N5O3/c1-4-21(30)28-9-7-18(8-10-28)29-14-17(22-23(25)26-15-27-24(22)29)6-5-16-11-19(31-2)13-20(12-16)32-3/h4,11-15,18H,1,7-10H2,2-3H3,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161451 (US10124003, Ex. Compound 64 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C24H25N5O3/c1-4-21(30)28-9-7-18(8-10-28)29-14-17(22-23(25)26-15-27-24(22)29)6-5-16-11-19(31-2)13-20(12-16)32-3/h4,11-15,18H,1,7-10H2,2-3H3,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161451 (US10124003, Ex. Compound 64 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CCN(CC2)C(=O)C=C)c2ncnc(N)c12 Show InChI InChI=1S/C24H25N5O3/c1-4-21(30)28-9-7-18(8-10-28)29-14-17(22-23(25)26-15-27-24(22)29)6-5-16-11-19(31-2)13-20(12-16)32-3/h4,11-15,18H,1,7-10H2,2-3H3,(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
					More data for this Ligand-Target Pair