BDBM162183 US9682995, 82

SMILES: Cc1nsc(Nc2cncc(n2)C(F)(F)F)c1C(=O)Nc1ccc(F)c(F)c1

InChI Key: InChIKey=QAQNENKIWLGPLT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 162183   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM162183 (US9682995, 82) Show SMILES Cc1nsc(Nc2cncc(n2)C(F)(F)F)c1C(=O)Nc1ccc(F)c(F)c1 Show InChI InChI=1S/C16H10F5N5OS/c1-7-13(14(27)23-8-2-3-9(17)10(18)4-8)15(28-26-7)25-12-6-22-5-11(24-12)16(19,20)21/h2-6H,1H3,(H,23,27)(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.7	22
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description N-terminally GST-tagged human full length recombinant Mps-1 kinase (purchased from Invitrogen, Karslruhe, Germany, cat. no PV4071) was used. As subst...				US Patent US9682995 (2017) BindingDB Entry DOI: 10.7270/Q2WH2N5Q
					More data for this Ligand-Target Pair
Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085) (Homo sapiens (Human))	BDBM162183 (US9682995, 82) Show SMILES Cc1nsc(Nc2cncc(n2)C(F)(F)F)c1C(=O)Nc1ccc(F)c(F)c1 Show InChI InChI=1S/C16H10F5N5OS/c1-7-13(14(27)23-8-2-3-9(17)10(18)4-8)15(28-26-7)25-12-6-22-5-11(24-12)16(19,20)21/h2-6H,1H3,(H,23,27)(H,24,25)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	8.0	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff...				US Patent US9682995 (2017) BindingDB Entry DOI: 10.7270/Q2WH2N5Q
					More data for this Ligand-Target Pair