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SMILES: COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c2ccccc2[nH]c1=O

InChI Key: InChIKey=NTSTWZGGDWDVKV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163106   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transitional endoplasmic reticulum ATPase (Homo sapiens (Human))	BDBM163106 (US9062026, Table III, Compound 34) Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C23H19N5O2/c1-30-19-13-7-10-16-20(19)26-22(27-21(16)24-14-15-8-3-2-4-9-15)28-18-12-6-5-11-17(18)25-23(28)29/h2-13H,14H2,1H3,(H,25,29)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cleave Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of human p97 ATPase incubated for 15 mins by ADP Glo luminescence assay				J Med Chem 58: 9480-97 (2015) Article DOI: 10.1021/acs.jmedchem.5b01346 BindingDB Entry DOI: 10.7270/Q2KW5K2P
					More data for this Ligand-Target Pair
Transitional endoplasmic reticulum ATPase (Homo sapiens (Human))	BDBM163106 (US9062026, Table III, Compound 34) Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C23H19N5O2/c1-30-19-13-7-10-16-20(19)26-22(27-21(16)24-14-15-8-3-2-4-9-15)28-18-12-6-5-11-17(18)25-23(28)29/h2-13H,14H2,1H3,(H,25,29)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<2.00E+3	n/a	n/a	n/a	n/a	7.5	37
Cleave Biosciences, Inc. US Patent					Assay Description The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...				US Patent US9062026 (2015) BindingDB Entry DOI: 10.7270/Q2765D32
					More data for this Ligand-Target Pair