BDBM163826 US9062070, 81::US9062070, 82
SMILES: Fc1ccc([C@@H]2CN3CCN(C[C@@H]3CO2)C(=O)C2CCc3nc(ncc23)-n2cnnn2)c(Cl)c1[N+]#[C-]
InChI Key: InChIKey=KWBYMUBAIAICGT-QWYDSHIESA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat)) | BDBM163826 (US9062070, 81 | US9062070, 82) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu... | US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat)) | BDBM163826 (US9062070, 81 | US9062070, 82) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L... | US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat)) | BDBM163826 (US9062070, 81 | US9062070, 82) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | 37 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L... | US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat)) | BDBM163826 (US9062070, 81 | US9062070, 82) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu... | US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX | |||||||||||
More data for this Ligand-Target Pair |