BDBM163879 US9062078, 11::US9062078, 12A::US9062078, 12B::US9475819, 11::US9637496, 12B::US9695183, 12B
SMILES: Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccccc2-c2cccs2)nc1
InChI Key: InChIKey=JIEFEDOEWSOKJT-UHFFFAOYSA-N
Data: 20 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3 | -10.8 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s... | US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3 | -10.8 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ... | US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5 | -11.9 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%... | US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5 | -11.9 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F... | US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10 | -10.1 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
Janssen Pharmaceutica NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9475819 (2016) BindingDB Entry DOI: 10.7270/Q2DZ0771 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10 | -10.1 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 10 | -10.1 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s... | US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12 | -11.3 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%... | US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ... | US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12 | -11.3 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F... | US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12 | -11.3 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ... | US Patent US9475819 (2016) BindingDB Entry DOI: 10.7270/Q2DZ0771 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 177 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 177 | -8.56 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ... | US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 177 | -8.56 | n/a | n/a | n/a | n/a | n/a | n/a | 4 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM001525) or Chinese ovary cells (CHO) s... | US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 339 | -9.26 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%... | US Patent US9695183 (2017) BindingDB Entry DOI: 10.7270/Q2N58JHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 339 | -9.26 | n/a | n/a | n/a | n/a | n/a | n/a | 40 |
JANSSEN PHARMACEUTICA NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% F... | US Patent US9062078 (2015) BindingDB Entry DOI: 10.7270/Q2RX99V3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM163879 (US9062078, 11 | US9062078, 12A | US9062078, 12B | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 339 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ... | US Patent US9637496 (2017) BindingDB Entry DOI: 10.7270/Q24J0H68 | |||||||||||
More data for this Ligand-Target Pair |