BDBM16957 6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-(furan-2-yl)pyridin-3-yl}isoquinoline::Isoquinoline-pyridine, 10d

SMILES: N[C@H](COc1cnc(-c2ccco2)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12

InChI Key: InChIKey=FLJJFPVRCWLXIM-QHCPKHFHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16957   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM16957 (6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-(fu...) Show SMILES N[C@H](COc1cnc(-c2ccco2)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C29H24N4O2/c30-23(13-22-16-32-27-5-2-1-4-25(22)27)18-35-24-14-26(29(33-17-24)28-6-3-11-34-28)20-7-8-21-15-31-10-9-19(21)12-20/h1-12,14-17,23,32H,13,18,30H2/t23-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Inhibition of Akt				Eur J Med Chem 44: 4090-7 (2009) Article DOI: 10.1016/j.ejmech.2009.04.050 BindingDB Entry DOI: 10.7270/Q2GT5N74
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM16957 (6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-(fu...) Show SMILES N[C@H](COc1cnc(-c2ccco2)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C29H24N4O2/c30-23(13-22-16-32-27-5-2-1-4-25(22)27)18-35-24-14-26(29(33-17-24)28-6-3-11-34-28)20-7-8-21-15-31-10-9-19(21)12-20/h1-12,14-17,23,32H,13,18,30H2/t23-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 3150-5 (2006) Article DOI: 10.1016/j.bmcl.2006.03.041 BindingDB Entry DOI: 10.7270/Q2F769TT
					More data for this Ligand-Target Pair