BDBM17023 (3Z)-5-hydroxy-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,3-dihydro-1H-indol-2-one::Indolinone based inhibitor, 2a

SMILES: C\C(=C1\C(=O)Nc2ccc(O)cc12)c1ccc[nH]1

InChI Key: InChIKey=WJTAKRSFNCCLHP-JYRVWZFOSA-N

Data: 1 IC50

PDB links: 1 PDB ID matches this monomer. 1 PDB ID contains this monomer as substructures.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 17023   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human))	BDBM17023 ((3Z)-5-hydroxy-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,...) Show SMILES C\C(=C1\C(=O)Nc2ccc(O)cc12)c1ccc[nH]1 Show InChI InChI=1S/C14H12N2O2/c1-8(11-3-2-6-15-11)13-10-7-9(17)4-5-12(10)16-14(13)18/h2-7,15,17H,1H3,(H,16,18)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3814-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.071 BindingDB Entry DOI: 10.7270/Q25Q4TBB
					More data for this Ligand-Target Pair				3D Structure (crystal)