BDBM171832 US9085584, 2

SMILES: Cc1ccc2nc(C)c3nnc(-c4cc(O)ccc4Cl)n3c2n1

InChI Key: InChIKey=WREDJOGPAYNGKD-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 171832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM171832 (US9085584, 2) Show SMILES Cc1ccc2nc(C)c3nnc(-c4cc(O)ccc4Cl)n3c2n1 Show InChI InChI=1S/C16H12ClN5O/c1-8-3-6-13-16(18-8)22-14(9(2)19-13)20-21-15(22)11-7-10(23)4-5-12(11)17/h3-7,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For all experiments the Phosphodiesterase [3H]cAMP SPA Enzyme Assay (TRKQ7090, GE Healthcare Europe GmbH) were used. The enzymatic activity of the PD...				US Patent US9085584 (2015) BindingDB Entry DOI: 10.7270/Q27P8X54
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM171832 (US9085584, 2) Show SMILES Cc1ccc2nc(C)c3nnc(-c4cc(O)ccc4Cl)n3c2n1 Show InChI InChI=1S/C16H12ClN5O/c1-8-3-6-13-16(18-8)22-14(9(2)19-13)20-21-15(22)11-7-10(23)4-5-12(11)17/h3-7,23H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US9085584 (2015) BindingDB Entry DOI: 10.7270/Q27P8X54
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM171832 (US9085584, 2) Show SMILES Cc1ccc2nc(C)c3nnc(-c4cc(O)ccc4Cl)n3c2n1 Show InChI InChI=1S/C16H12ClN5O/c1-8-3-6-13-16(18-8)22-14(9(2)19-13)20-21-15(22)11-7-10(23)4-5-12(11)17/h3-7,23H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The inhibition of PDE 2A or 10 enzyme activity was assessed using IMAP-Phosphodiesterase-cAMP fluorescence labeled substrate (Molecular Devices, Orde...				US Patent US9085584 (2015) BindingDB Entry DOI: 10.7270/Q27P8X54
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM171832 (US9085584, 2) Show SMILES Cc1ccc2nc(C)c3nnc(-c4cc(O)ccc4Cl)n3c2n1 Show InChI InChI=1S/C16H12ClN5O/c1-8-3-6-13-16(18-8)22-14(9(2)19-13)20-21-15(22)11-7-10(23)4-5-12(11)17/h3-7,23H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For assessing activity of compounds on PDE10 inhibition, the following modifications of the protocol described below are applied: protein amount: ...				US Patent US9085584 (2015) BindingDB Entry DOI: 10.7270/Q27P8X54
					More data for this Ligand-Target Pair