null

SMILES: CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C

InChI Key: InChIKey=AYZRGQPKPDHNAX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 172635   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.721	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.65	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.735	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.864	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.08	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM172635 (US9090628, 295 | US9090628, 302 | US9090628, 312 |...) Show SMILES CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(C)c1C1CC(CCO1)N(C)C Show InChI InChI=1S/C28H36N8O2/c1-17(2)36-28(30-18(3)32-36)23-16-35-10-12-38-24-13-19(7-8-21(24)27(35)31-23)22-15-29-34(6)26(22)25-14-20(33(4)5)9-11-37-25/h7-8,13,15-17,20,25H,9-12,14H2,1-6H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.951	n/a	n/a	n/a	n/a	7.5	n/a
GENENTECH, INC. US Patent					Assay Description PI3K enzymatic activity was assayed by measuring the amount of product phosphatidylinositol 3,4,5-phosphate (PIP3) formed from substrate 4,5 phosphat...				US Patent US9090628 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W0V
					More data for this Ligand-Target Pair