BDBM173467 US9096606, 4
SMILES: CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccc(F)cc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CC[N]1(C)CC1CC1)c45
InChI Key: InChIKey=PXKALUFKETXVGA-BWTJNEPQSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM173467 (US9096606, 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.260 | -12.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Purdue Pharma, L.P. US Patent | Assay Description Membranes from recombinant HEK-293 cells expressing the human kippa opioid receptor (cloned in house) were prepared by lysing cells in ice cold hypot... | US Patent US9096606 (2015) BindingDB Entry DOI: 10.7270/Q2J101XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM173467 (US9096606, 4) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 9.55 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 50 |
Purdue Pharma, L.P. US Patent | Assay Description Radioligand dose-displacement binding assays for -opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane ... | US Patent US9096606 (2015) BindingDB Entry DOI: 10.7270/Q2J101XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM173467 (US9096606, 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 175 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma, L.P. US Patent | Assay Description δ-opioid Receptor Binding Assay Procedures were conducted as follows. Radioligand dose-displacement assays used 0.3 nM [3H]-Naltrindole (Perkin ... | US Patent US9096606 (2015) BindingDB Entry DOI: 10.7270/Q2J101XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Opioid growth factor receptor-like protein 1 (Homo sapiens (Human)) | BDBM173467 (US9096606, 4) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | >2.00E+4 | >-5.95 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Purdue Pharma, L.P. US Patent | Assay Description Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Perkin Elmer, Shelton, Conn.) were prepared by l... | US Patent US9096606 (2015) BindingDB Entry DOI: 10.7270/Q2J101XF | |||||||||||
More data for this Ligand-Target Pair |