BDBM17471 1,2,3-triazole analogue, 27::3-(1H-1,2,3-triazol-5-yl)pyridine

SMILES: c1[nH]nnc1-c1cccnc1

InChI Key: InChIKey=VYXFEFOIYPNBFK-UHFFFAOYSA-N

Data: 1 KI  4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Methionine aminopeptidase 2 (Homo sapiens (Human))	BDBM17471 (1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...) Show SMILES c1[nH]nnc1-c1cccnc1 Show InChI InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	260	-8.89	n/a	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...				J Med Chem 48: 5644-7 (2005) Article DOI: 10.1021/jm050408c BindingDB Entry DOI: 10.7270/Q26M3537
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM17471 (1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...) Show SMILES c1[nH]nnc1-c1cccnc1 Show InChI InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	6.5	n/a
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...				J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3 (SIRT3) (Homo sapiens (Human))	BDBM17471 (1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...) Show SMILES c1[nH]nnc1-c1cccnc1 Show InChI InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi del Piemonte Orientale A. Avogadro Curated by ChEMBL					Assay Description Inhibition of human SIRT3 expressed in Escherichia coli using Z-MAL as substrate after 6 hrs by fluorescence assay				Eur J Med Chem 55: 58-66 (2012) Article DOI: 10.1016/j.ejmech.2012.07.001 BindingDB Entry DOI: 10.7270/Q20K29NG
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM17471 (1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...) Show SMILES c1[nH]nnc1-c1cccnc1 Show InChI InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate after 30 mins by micro...				Eur J Med Chem 46: 5680-7 (2011) Article DOI: 10.1016/j.ejmech.2011.08.044 BindingDB Entry DOI: 10.7270/Q2KH0NRS
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM17471 (1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...) Show SMILES c1[nH]nnc1-c1cccnc1 Show InChI InChI=1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AI				J Med Chem 53: 1172-89 (2010) Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9
					More data for this Ligand-Target Pair