BDBM176352 US9688696, 68

SMILES: Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccccc2C(F)(F)F)cc1

InChI Key: InChIKey=PSIXZVJABBBOPU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 176352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM176352 (US9688696, 68) Show SMILES Cc1ccc(Cn2ncc3nc([nH]c23)-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2ccccc2C(F)(F)F)cc1 Show InChI InChI=1S/C30H28F3N7O/c1-20-6-8-21(9-7-20)19-40-28-26(18-34-40)35-27(37-28)22-10-12-23(13-11-22)38-14-16-39(17-15-38)29(41)36-25-5-3-2-4-24(25)30(31,32)33/h2-13,18H,14-17,19H2,1H3,(H,35,37)(H,36,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	129	n/a	n/a	n/a	n/a	7.4	25
Janssen Pharmaceutica N.V. US Patent					Assay Description DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...				US Patent US9688696 (2017) BindingDB Entry DOI: 10.7270/Q24X55ZP
					More data for this Ligand-Target Pair